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Principal Investigator: Dominic Mosha
Project leader/ Coordinator: Dominic Mosha
Project Administrator: Priscilla Mlay
Funding Partner: European and Developing Countries Clinical Trials Partnership Programme (EDCTP)
Start date: April 1, 2019
End date: Dec. 31, 2022
The project aims to determine readiness, challenges and policy options for effective roll out of recommended malaria treatment regimen in routine healthcare. This is a repeated cross-sectional study involving clinicians as a primary study, population treating uncomplicated malaria patients with ACT+PQ regardless their G6PD status, 7 days follow up and management of adverse events (secondary study population, malaria patients).
It will involve the following process: Needs assessment survey of 16 random selected facilities in two rural districts including human resources; laboratory capacity and medical supplies Equip 6 random sampled intervention facilities with basic tools and supplies essential for monitoring and managing G6PD adverse events; training health care providers on PQ roll out monitoring pharmacovigilance tool (PROMPT); adoption of the PROMPT tool by healthcare providers in malaria treatment using ACT+PQ for the period of 6 months with minimal provider supervision; assess healthcare providers challenges and revise the training package by validating the PROMPT; piloting the revised training package; and safety monitoring tool for 4 months.
Finally, a comprehensive safety training package will be produced. To improve the training manual, in-depth interviews will be conducted to determine providers and clients experience. Furthermore, needs for a successful rollout of ACT + PQ treatment regimen will be determined by key informants’ interview which will involve officers from the Ministry of Health, National Malaria Control Program (NMCP), and safety drug monitoring board. #